What's in this article?
What is a reactive Lymphocytes?
Reactive lymphocytes are lymphocytes that become large as a result of antigen stimulation. Typically they can be more than 30 µm in diameter with varying size and shape. The nucleus of a reactive lymphocyte can be round, elliptic, indented, cleft or folded. The cytoplasm is often abundant and can be basophilic.
Reactive vs neoplastic?
Reactive lymphocytes should be distinguished from neoplastic hematopoietic cells. This is particularly the case when the cells in question are large or “big blue” cells. Refer to the diagnostic algorithm and table in the related links below for help to determine if a large mononuclear cell with blue cytoplasm is a reactive lymphocyte or a neoplastic “blast”.
read more about Relative Lymphocytosis in Children and Adult
Causes Of Reactive Lymphocytes
There are several factors that are responsible for atypical lymphocytes.
These atypical lymphocytes are either folded, round, indented or elliptic in shape. They have basophilic cytoplasm and contain several vacuoles. In general these lymphocytes are gray, deep blue or pale blue in color. They are often found in association with a viral or a protozoan infection in the body.